PODCAST
When Your Immune System Goes Rogue: Mast Cells, Pelvic Pain & Hot Flashes
June 9, 2026·8:18·Episode 54
Quick Summary
Today we're exploring how your immune system behaves during menopause, from new research on inflammatory markers that drive hot flashes to mast cell activation syndrome causing mysterious symptoms. Plus, we're talking about pelvic pain and bladder issues that many women experience but rarely connect to hormonal changes.
When Your Immune System Goes Rogue: Mast Cells, Pelvic Pain & Hot Flashes
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Key Takeaways
- ✦Specific inflammatory markers IL-26 and IL-38 may drive the intensity of hot flashes and vasomotor symptoms
- ✦Mast cell activation syndrome can cause anxiety, food sensitivities, and histamine reactions during perimenopause
- ✦Interstitial cystitis and pelvic pain often emerge or worsen during menopause due to hormonal changes
- ✦Both estrogen and testosterone play crucial roles in bladder and pelvic floor function
- ✦Women are disproportionately affected by mast cell-related conditions, especially during hormonal transitions
Sources & References
Hot Flasher provides informational content only and does not constitute medical advice. Always consult a qualified healthcare provider for medical concerns.